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She then reunited with Peter O'Toole in the BBC TV drama Casanova.
Byrne appeared with Snoop Dogg in Danny Green's film The Tenants, based on Bernard Malamud's novel, and starred as Alex with Josh Hartnett and Diane Kruger in the romantic psychological thriller Wicker Park.
Yet there will be a return for Vince, who even before the finale had an on-off romance with Will - though how long Vince will be back remains unknown.
The year previously she had flown to the UK to shoot I Capture the Castle, Tim Fywell's adaptation of the 1948 novel of the same title by Dodie Smith.
Will & Grace is being revived by NBC, where it'll return next Thursday - but as its creators told Entertainment Weekly last month, there's a twist.
The romantic happy endings the title characters got in the 2006 finale have been scuppered, and Will and Grace's children have been written out of the story.
Later that year, she appeared in the indie film Adam, with Hugh Dancy.
She appeared in the 2010 comedy film Get Him to the Greek, starring Russell Brand and Jonah Hill, and she was co-lead in the James Wan horror film Insidious, which premiered in September 2010 at the Toronto International Film Festival In 2013, Byrne appeared in the crime drama The Place Beyond the Pines, with Ryan Gosling and Bradley Cooper, and appeared in the comedy, The Internship, opposite Vince Vaughn and Owen Wilson; and The Turning, a short film installment in a Tim Winton omnibus feature.